Inhibitors of protein isoprenyl transferases

A compound having Formula I

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is phenyl, wherein the phenyl is unsubstituted or substituted with loweralkyl;
• R2 is selected from the group consisting of —L11—C(R14)(Rv)—C(O)OR15 and —C(O)NH—CH(R14)—C(O)NHSO2R16;
• wherein
• L11 is —C(O)—;
• Rv is hydrogen;
• R14 is selected from the group consisting of alkylsulfonylalkyl and thioalkoxyalkyl;
• R15 is selected from the group consisting of hydrogen and loweralkyl;
• R16 is aryl, wherein the aryl is unsubstituted or substituted with a substituent selected from the group consisting of loweralkyl and halogen;
• L1 is —L4—O—L5—, wherein
• L4 is absent or selected from the group consisting of C1-to-C10-alkylene and C2-to-C16-alkenylene, wherein the alkylene and alkenylene groups are unsubstituted or substituted with 1, 2 or 3 substitutents independently selected from the group consisting of alkoxyalkyl, alkyl[S(O)q]alkyl, arylalkyl, hydroxyl, cycloalkoxyalkyl, cycloalkylalkyl, oxo, and arylalkoxyalkyl, wherein the arylalkoxyalkyl is unsubstituted or substituted with alkoxy;
• q is zero, one or two;
• L5 is absent or selected from the group consisting of C1-to-C10-alkylene and C2-to-C16-alkenylene wherein the alkylene and alkenylene is unsubstituted or substituted as defined previously;
• with the proviso that at least one of L4 and L5 is not absent;
• Z is a covalent bond;
• R3 is selected from the group consisting of aryl, cycloalkyl, and cycloalkenyl, wherein the aryl is unsubstituted or substituted with a substituent selected from the group consisting of alkanoyl, alkoxyalkyl, alkoxycarbonyl, arylalkyl, aryl, aryloxy, (aryl)oyl, carboxaldehyde, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, halogen, haloalkyl, hydroxyl, hydroxyalkyl, loweralkyl, nitro, —NRR′, thioalkoxy, and alkoxy, wherein the alkoxy is unsubstituted or substituted with cycloalkyl;
• wherein
• R and R′ are independently selected from the group consisting of hydrogen and loweralkyl;
• and
• R4 is selected from the group consisting of hydrogen and arylalkyl.