Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
AssigneeAmerican Cyanamid Company
InventorsBernard Beer, Joseph William Epstein
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Abstract
The invention is a method of treatment for the relief of an addictive, compulsive disorder which comprises the administration to a human or animal suffering from such a disorder an effective amount of the compound of the formula: wherein R is hydrogen, alkyl (C1-C6); R1 is hydrogen, mono or disubstituted halogen, alkoxy (C1-C3), CF3, alkyl (C1-C6); and R2 is hydrogen, methyl or ethyl, or a pharmaceutically acceptable salt thereof.
Claims24
A method for treatment of an addictive, compulsive disorder caused by alcohol or cocaine abuse, which comprises the administration to a human or animal suffering from such a disorder, an effective amount of the compound of the formula:
- in which R is hydrogen or alkyl of 1-6 carbon atoms;
- R1 is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to 3 carbon atoms, CF3 or alkyl of 1-6 carbon atoms;
- and
- R2 is hydrogen, methyl or ethyl;
- or a pharmaceutically acceptable salt thereof.
A method for treatment of drug dependence caused by alcohol or cocaine abuse, which comprises administering to a human or animal suffering from or dependent on a drug, an effective amount of the compound of the formula:
- in which R is hydrogen or alkyl of 1-6 carbon atoms;
- R1 is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to 3 carbon atoms, CF3 or alkyl of 1-6 carbon atoms;
- and
- R2 is hydrogen, methyl or ethyl;
- or a pharmaceutically acceptable salt thereof.
A method for treatment of an addictive, compulsive disorder caused by alcohol abuse, which comprises the administration to a human or animal suffering from such a disorder, an effective amount of the compound of the formula:
- in which R is hydrogen or alkyl of 1-6 carbon atoms;
- R1 is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to 3 carbon atoms, CF3 or alkyl of 1-6 carbon atoms;
- and
- R2 is hydrogen, methyl or ethyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.