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US 6,204,280 B1Granted
Adhesion receptor antagonists
AssigneeMerck Patent Gesellschaft mit berschrankter Haftung
InventorsJoachim Gante, Horst Juraszyk, Peter Raddatz, Hanns Wurziger, Sabine Bernotat-Danielowski, Guido Melzer, Matthias Wiesner, Claus Fittschen
Life of this patent
Estimating the term…
Abstract
Compounds of the formula I wherein R1, R2 and R3 have the meanings defined herein, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be employed for the treatment of thromboses, osteoporoses, oncoses, apoplexy, cardiac infarct, ischaemias, inflammations, arteriosclerosis and osteolytic disorders.
Claims8
An oxazolidinone compound of formula I
- wherein
- R1 is
- R2 is H, A, Ac, A—SO2—, Ar—SO2— or the amino protective group, BOC;
- R3 is H, A, cycloalkyl having 3 to 7 C atoms, Ar or Ar—(CH2)k—;
- A is alkyl having 1 to 16 C atoms;
- D is H2N—CH2—, H2N—C(═NH)— or H2N—C(═NH)—NH—CH2—, wherein primary amino groups in each case can optionally be provided with amino protective groups;
- Ac is alkanoyl having 1 to 10 C atoms or benzoyl or napththoyl having 7 to 11 C atoms;
- Ar is benzyl, unsubstituted phenyl or phenyl which is mono- or disubstituted by A, Cl, Br, I, OA, OH, NO2, CN, NH2, NHA, NA2 or combinations thereof;
- and
- k is 2, 3 or 4;
- or
- a physiologically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.