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US 6,204,277 B1Granted
Propionic acid derivatives and applications thereof
AssigneeJapan Tobacco Inc.
InventorsHisashi Shinkai, Tsutomu Shibata, Satoshi Ohrui
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Abstract
A novel propionic acid derivative of the formula (I): and a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing the derivative. The propionic acid derivative and a pharmaceutically acceptable salt thereof have superior hypoglycemic action and are expected to show hypolipidemic action and to be useful as therapeutic agents for diabetes and complications of diabetes, as well as related diseases such as hyperlipemia.
Claims7
A novel propionic acid derivative of the formula (I):
- wherein R is a group of the formula:
- wherein
- R′ is an optionally substituted aromatic hydrocarbon, an optionally substituted alicyclic hydrocarbon, an optionally substituted heterocyclic group or an optionally substituted fused heterocyclic group, and
- R5 is a lower alkyl;
- R4 is a hydrogen atom or a lower alkyl;
- R6 is a hydrogen atom;
- R7 is carboxy, an acyl, an optionally substituted alkoxycarbonyl, an optionally substituted lower alkyl, an optionally substituted carbamoyl, an optionally substituted aryloxycarbonyl, or an optionally substituted aralkyloxycarbonyl;
- R9 is a hydrogen atom, an optionally substituted lower alkyl or an optionally substituted alkoxycarbonyl;
- and
- R10 is a hydroxy, an optionally substituted amino, an optionally substituted lower alkoxy, an optionally substituted lower alkyl, an optionally substituted aryloxy, or an optionally substituted aralkyloxy;
- provided that when R7 is an alkoxycarbonyl and R9 is a hydrogen atom, R10 is not a lower alkoxy,
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.