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US 6,204,275 B1Granted
PDE IV inhibiting compounds, compositions and methods of treatment
AssigneeMerck Frosst Canada, Inc.
InventorsRichard Friesen, Yvbes Ducharme, Daniel Dube, Yves Girard, Richard Frenette, Chun Li, Marc Blouin, Nathalie Chauret, Laird Trimble
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Abstract
The invention encompasses compounds of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.
Claims22
A compound represented by formula I:
- or a pharmaceutically acceptable salt thereof wherein:
- each Ra independently represents a member selected from the group consisting of H, C1-6alkyl and haloC1-6alkyl;
- Rb represents a member selected from the group consisting of H, C1-6alkyl, haloC1-6alkyl;
- each R1 independently represents a member selected from the group consisting of:
- C1-10alkyl, aryl, heteroaryl, substituted C1-10alkyl, substituted aryl and substituted heteroaryl, wherein the substituents are 1-6 members selected from the group consisting of C1-4alkyl, halo, hydroxy, haloC1-4alkyl, CN, C1-4alkoxy, C1-4alkylthio, C1-4alkyl-SO2— and H2NSO2—;
- and
- when present, each R2 independently represents a member selected from the group consisting of halo, C1-6alkyl, haloC1-6alkyl and CN.
4 more elements
Dependencies are inferred from the claim text.