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US 6,204,272 B1Granted
Use of aminothiazoles for treating wounds and skin
AssigneeBayer Aktiengesellschaft
InventorsKlaus Schaller, Bernd Baasner, Magdalena Liszkay, Hans-Otto Werling, Ehrhardt Proksch
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of substituted 2-aminothiazoles for promoting wound healing.
Claims6
A method for improving the wound healing of a patient in need thereof, which comprises administering to said patient, an effective amount therefor of a 2-aminothiazole of the formula (I)
- in which
- R1 represents hydrogen or represents straight-chain or branched alkyl having 1 to 4 carbon atoms and
- R2 represents a radical of the formula
- where
- R3, R4, R5 and R6 independently of one another each represent hydrogen, fluorine, chlorine, bromine, iodine, nitro, represent in each case straight-chain or branched alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl having in each case 1 to 4 carbon atoms in the respective alkyl moieties or represent in each case straight-chain or branched halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl or halogenoalkylsulphonyl having in each case 1 to 4 carbon atoms and 1 to 9 identical or different halogen atoms
- X represents oxygen, sulphur, sulphinyl or sulphonyl and
- Ar represents phenyl, α-naphthyl, β-naphthyl, tetrahydronaphthyl or indanyl, each of which is optionally mono- or polysubstituted by identical or different substituents, the substituents being in each case:
- fluorine, chlorine, bromine, iodine, in each case straight-chain or branched alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl having in each caase 1 to 8 carbon atoms in the respective alkyl moieties, in each case straight-chain or branched halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl or halogenoalkylsulphonyl having in each case 1 to 4 carbon atoms and 1 to 9 identical or different halogen atoms, cycloalkyl having 3 to 7 carbon atoms, phenylalkyl or phenoxyalkyl having in each case 1 to 4 carbon atoms in the straight-chain or branched alkyl moiety and also phenyl or phenoxy,
- or a physiologically tolerable acid addition salt thereof.
6 more elements
Dependencies are inferred from the claim text.