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US 6,204,257 B1Granted
Water soluble prodrugs of hindered alcohols
AssigneeUniverstiy of Kansas
InventorsValentino J. Stella, Jan J. Zygmunt, Ingrid Gunda Georg, Muhammad S. Safadi
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Abstract
The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.
Claims28
A compound according to formula I:
- wherein,
- R—O— is a residue of a phenol containing pharmaceutical compound,
- R1 Is hydrogen or an alkali metal ion or a protonated amine or a protonated amino acid,
- R2 is hydrogen or an alkali metal ion or a protonated amine or a protonated amino acid, and
- n is an integer of 1 or 2;
- and pharmaceutically acceptable salts thereof.
3 more elements
A compound selected from the group consist of:
- wherein Z is selected from the group consisting of hydrogen, alkali metal ion, and anine;
- and pharmaceutically acceptable salts thereof.
A compound according to formula IV:
- wherein,
- R—O— is a residue of a phenol-containing pharmaceutical compound,
- Y is a phosphono protecting group, and
- n is an integer of 1 or2;
- and pharmaceutically acceptable salts thereof.
2 more elements
The compound according to formula I,
- wherein,
- R—O is a residue of propofol,
- R1 is hydrogen or an alkali metal ion or a protonated amine or a protonated amino acid,
- R2 is hydrogen or an alkali metal ion or a protonated amine or a protonated amino acid, and
- n is an integer of 1 or 2;
- and pharmaceutically acceptable salts thereof.
3 more elements
A compound
- wherein Z is selected from the group consisting of hydrogen, alkali metal ion and amine, and n is an integer of 1 or 2;
- and pharmaceutically acceptable salts thereof.
The compound according to Formula I,
- wherein
- R—O is a residue of propofol
- Y is a phosphono protecting group, and
- n is an integer of 1 or 2;
- and pharmaceutically acceptable salts thereof.
2 more elements
A compound:
- wherein Y is a phosphono protecting group.
Dependencies are inferred from the claim text.