Pharmaceutical preparations of glutathione and methods of administration thereof
AssigneeAntioxidant Pharmaceuticals Corp.
InventorsHarry B. Demopoulos, Myron L. Seligman
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Abstract
A method of altering an expression of a gene product in cells or an organism, comprising orally administering glutathione in an effective amount and under such conditions to alter a redox potential in the cells. The gene expression may be sensitive to redox potential through one or more of a process of induction, transcription, translation, post-translational modification, release, and/or through a receptor mediated process. The glutathione is preferably administered as an oral bolus of encapsulated pharmaceutically stabilized glutathione in a rapidly dissolving formulation to a mammal on an empty stomach.
Claims14
A method, comprising administering a sufficient oral dose of reduced glutathione to alter a cellular redox potential and thereby modify production of gene products.
A method of altering an expression of gene products in mammalian cells comprising orally administering reduced glutathione to achieve an effective concentration in the duodenum of at least about 500 micromolar, with less than about 10 grams of food present per gram of glutathione in the duodenum.
Dependencies are inferred from the claim text.