Amino acid compositions and use thereof in immunosuppression
AssigneeNovartis Nutrition AG
InventorHeinz Schneider
Life of this patent
Estimating the term…
Abstract
The present invention provides for the use glycine in the preparation of a medicament or nutritional formulation for the prophylaxis and/or therapy of renal dysfunction induced by cyclosporins or ascomycins.
Claims12
A method for the prophylactic and/or therapeutic treatment of renal dysfunction induced by cyclosporins or ascomycins comprising enterally administering to a human being or other mammal simultaneous with the treatment with a cyclosporin or ascomycin, a medicament or nutritional formulation comprising an amino acid component consisting essentially of glycine in an amount effective to inhibit and/or ameliorate the renal dysfunction, a carbohydrate source, and optionally one or more components selected from vitamins, minerals, trace elements, and fibers.
An enteral medicament or nutritional formulation comprising a therapeutically effective amount of a cyclosporin or ascomycin in combination with an amino acid component consisting essentially of glycine in an amount effective to inhibit and/or ameliorate the renal dysfunction induced by said cyclosporin or ascomycin, and 25 to 75% carbohydrate by weight of the medicament or nutritional formulation, and one or more components selected from vitamins, minerals and trace elements, wherein glycine is present in an amount of about 0.2 to 60 g per 100 g dry weight of the medicament or nutritional formulation.
Dependencies are inferred from the claim text.