Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis

A method of treating Crohn's disease, ulcerative colitis, or inflammatory occurrences associated therewith, wherein the method comprises:

• orally administering a pharmaceutical preparation comprising
• 1) a pharmaceutically acceptable solvent in which cyclosporin A is soluble,
• 2) cyclosporin A in an amount effective for treating Crohn's disease, ulcerative colitis, or inflammatory occurrences associated therewith, wherein the cyclosporin A is dissolved in the pharmaceutically acceptable solvent, forming a solution of the cyclosporin A in the pharmaceutically acceptable solvent,
• 3) a starch capsule or a hard or soft gelatin capsule which encapsulates the solution of the cyclosporin A;
• and
• 4) optionally, a medicament excipient selected from the group consisting of a surface-active agent and an agent which affects viscosity,
• wherein said capsule has been coated with at least one polymer composition containing at least one pore-forming agent in an amount effective to increase the diffusion rate through the polymer coating.

A process for the production of a pharmaceutical preparation comprising a starch capsule or a hard or soft gelatin capsule, and cyclosporin A in dissolved form, wherein the process comprises:

• 1) dissolving the cyclosporin A in a solvent which is suitable for encapsulation into starch or gelatin capsules, or in a mixture of several solvents and other excipients,
• 2) filling the solution into starch capsules, or hard or soft gelatin capsules in a measured dose,
• 3) sealing the capsules, and
• 4) coating the capsules with a solution or dispersion of a polymer or polymer mixture and drying the capsules, wherein the coating procedure may be repeated one or more times and the polymer solution or dispersion contains at least one pore-forming agent in an amount effective to increase the diffusion rate through the polymer coating.