TGF-β1 to improve neural outcome
AssigneeGenentech, Inc.
InventorsPeter Gluckman, Karoly Nikolics, Christopher Williams
Life of this patent
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Abstract
The invention relates to methods of treating injuries to or diseases of the central nervous system which methods involve increasing the active concentration(s) of transforming growth factor beta 1 (TGF-β1) and/or analogues thereof in the central nervous system of the patient. The present invention also provides pharmaceutical compositions comprising TGF-β1 and/or analogues thereof for administration to a patient prior to, simultaneous with, or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.
Claims6
A method of treating central nervous system injury in a mammal, comprising administering to the central nervous system of said mammal TGF-β1 in the period from the time of the central nervous system injury to about 8 hours after said injury and wherein TGF-β1 is administered to said mammal in an amount from about 0.0033 to about 0.15 μg of TGF-β1 per 100 gm of body weight of said mammal wherein said administration results in a reduction in the severity of central nervous system damage, wherein the central nervous system injury affects non-cholinergic neuronal cells.
A method of treating central nervous system injury in a mammal, comprising administering to the central nervous system of said mammal TGF-β1 in the period from the time of the central nervous system injury to about 8 hours after said injury and wherein TGF-β1 is administered to said mammal in an amount from about 0.0033 to about 0.15 μg of TGF-β1 per 100 gm of body weight of said mammal wherein said administration results in a reduction in the severity of central nervous system damage, wherein the central nervous system injury affects glial cells.
A method of treating central nervous system injury in a mammal, comprising administering to the central nervous system of said mammal TGF-β1 in the period from the time of the central nervous system injury to about 8 hours after said injury and wherein TGF-β1 is administered to said mammal in an amount from about 0.0033 to about 0.15 μg of TGF-β1 per 100 gm of body weight of said mammal wherein said administration results in a reduction in the severity of central nervous system damage, wherein the central nervous system injury is a consequence of Parkinson's disease.
A method of treating central nervous system injury in a mammal, comprising administering to the central nervous system of said mammal TGF-β1 in the period from the time of the central nervous system injury to about 8 hours after said injury and wherein TGF-β1 is administered to said mammal in an amount from about 0.0033 to about 0.15 μg of TGF-β1 per 100 gm of body weight of said mammal wherein said administration results in a reduction in the severity of central nervous system damage, wherein the central nervous system injury is a consequence of multiple sclerosis.
A method of treating central nervous system injury in a mammal, comprising administering to the central nervous system of said mammal TGF-β1 in the period from the time of the central nervous system injury to about 8 hours after said injury and wherein TGF-β1 is administered to said mammal in an amount from about 0.0033 to about 0.15 μg of TGF-β1 per 100 gm of body weight of said mammal wherein said administration results in a reduction in the severity of central nervous system damage, wherein the central nervous system injury is a consequence of a demyelinating disorder.
A method of treating central nervous system injury in a mammal, comprising administering to the central nervous system of said mammal TGF-β1 in the period from the time of the central nervous system injury to about 8 hours after said injury and wherein TGF-β1 is administered to said mammal in an amount from about 0.0033 to about 0.15 μg of TGF-β1 per 100 gm of body weight of said mammal wherein said administration results in a reduction in the severity of central nervous system damage, wherein the TGF-β1 is administered peripherally into the mammal for passage into the lateral ventricle of the brain.
Dependencies are inferred from the claim text.