Viral vectors and line for gene therapy
AssigneeTransgene S.A.
InventorsMajid Mehtali, Monika Lusky, Karola Rittner
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Abstract
Novel viral vectors in which the expression of viral genes is regulated in such a way that it is functional in a complementation cell and non-functional in a host cell, as well as viral particles and host cells containing said novel vectors, are disclosed. A complementation cell including a viral gene expression regulator, and a method for preparing infectious viral particles, are also disclosed. Finally, a pharmaceutical composition containing said vectors, and the therapeutical use thereof, are disclosed.
Claims42
Adenoviral vector, comprising an expression unit containing one or more viral genes;
- said expression unit being functional in a complementation cell and nonfunctional in a host cell, and comprising one or more heterologous regulator sequence(s).
Complementation cell which complements at least one adenoviral vector function, comprising an inducer and/or a repressor.
Dependencies are inferred from the claim text.