Loading patent…
AssigneeDiacrin, Inc.
InventorJonathan Dinsmore
Estimating the term…
Porcine neural cells and methods for using the cells to treat neurological deficits due to neurodegeneration are described. The porcine neural cells are preferably embryonic mesencephalic, embryonic striatal cells, or embryonic cortical cells. The porcine neural cells can be modified to be suitable for transplantation into a xenogeneic subject, such as a human. For example, the porcine neural cells can be modified such that an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in a xenogeneic subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof) to inhibit rejection of the cell when introduced into the subject. In one embodiment, the porcine neural cells are obtained from a pig which is essentially free from organisms or substances which are capable of transmitting infection or disease to the recipient subject. The porcine neural cells of the present invention can be used to treat neurological deficits due to neurodegeneration in the brain of a xenogeneic subject (e.g., a human with epilepsy, head trauma, stroke, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, or Huntington's disease) by introducing the cells into the brain of the subject.
A composition consisting essentially of porcine cerebral cortical cells dissociated from porcine cerebral cortex and a carrier.
A composition consisting essentially of porcine cerebral cortical cells dissociated from porcine cerebral cortex and obtained from a pig predetermined to be essentially fee from organisms or substances which are capable of transmitting infection or disease to a xenogeneic recipient of the cell and a carrier.
A composition consisting essentially of a population of porcine cerebral cortical cells dissociated from porcine cerebral cortex and a carrier, wherein at least one of the cells extend at least one neural process to at least one subcortical target region in the brain upon introduction of the composition into a subject.
A composition consisting essentially of porcine cerebral cortical cell. dissociated from porcine cerebral cortex and isolated from a pig which is essentially free from the following organism or substances:
Dependencies are inferred from the claim text.