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US 6,204,034 B1Granted
Leukotriene C4 synthase
AssigneeMerck Frosst Canada, Inc.
InventorDonald W. Nicholson
Life of this patent
Estimating the term…
Abstract
Leukotriene C4 synthase polypeptide identified by photoaffinity labelling, and purification of leukotriene C4 synthase to homogeneity is described.
Claims3
A LTC4 synthase, in substantially free form, having a molecular weight of 18 kDa as determined on silver stained SDS-polyacrylamide denaturing gel and having the partial amino-terminal sequence of SEQ ID NO:1:
- M K D E V A L L A A V T Met-Lys-Asp-Glu-Val-Ala-Leu-Leu-Ala-Ala-Val-Thr- L L G Leu-Leu-Gly- 15 V L L Q A G F S L Q V I Val-Leu-Leu-Gln-Ala-Gly-Phe-Ser-Leu-Gln-Val-Iso- S A R Ser-Ala-Arg- 30 X A F R V [Xaa]-Ala-Phe-Arg-Val-
- wherein X is I (Iso) or R (Arg).
Dependencies are inferred from the claim text.