Method for producing pravastatin precursor, ML-236B
AssigneeYungjin Pharameutical Ind. Co., Ltd.
InventorsKae Jong Chung, Joo Kyung Lee, Joo Woong Park, Dong Jin Seo, Sang Choon Lee
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Abstract
The present invention is related to a new method for producing ML-236B, a precursor of pravastatin sodium, in particular to a method for producing ML-236B lactone form(I), free acid form(II), sodium salt(III) shown in the formulae (I), (II), (III) by using a new microorganism isolated from soil. ML-236B is obtained from the culture broth of this microorganism and it is used as a substrate of pravastatin sodium which is a potent cholesterol-lowering agent used in treatment for hypercholesterolemia.
Claims3
A method for producing at least one compound of ML-236B slected from compounds of formulae I, II, and III, comprising:
- culturing, in a culture medium, Gliocladium sp. YJ-9515 having the accession number KCTC 0252 BP;
- and
- recovering said at least one compound of ML-236B;
- wherein the compound of formula I is the lactone form of ML-236B represented by
- wherein the compound of formula II is the free acid form of ML-236B represented by
- and
- wherein the compound of formula III is the sodium salt form of ML-236B represented by
A purified strain of Gliocladium sp. YJ-9515 (accession number KCTC 0252BP).
Dependencies are inferred from the claim text.