DNA encoding N∇2 CSF-1 (short form) and carboxy truncated fragment thereof
AssigneeChiron Corporation
InventorsMartha B. Ladner, Janelle N. Van Arsdell, George A. Martin, Ernest S. Kawasaki, Mazie Yee Coyne, Robert F. Halenbeck, Kirston E. Koths
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Abstract
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both “long” and “short” forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
Claims10
A DNA that encodes a carboxy truncated CSF-1 polypeptide consisting of amino acid residues 3 to 158 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.