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AssigneeSchering Corporation
InventorsJiang X. Behan, Joseph A. Hedrick, Thomas M. Laz, Frederick J. Monsma, Kelley L. Morse, Shelby P. Umland, Suke Wang
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The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.
An isolated or recombinant nucleic acid encoding an antigenic polypeptide, said polypeptide comprising at least 12 contiguous residues of the amino acid sequence of SEQ ID NO:
An isolated or recombinant nucleic acid encoding an antigenic polypeptide, said polypeptide comprising at least 20 contiguous residues of the amino acid sequence of SEQ ID NO. 2, wherein the nucleic acid is operably linked to a genetic control element.
An isolated or recombinant nucleic acid encoding an antigenic polypeptide, said polypeptide comprising at least 30 contiguous residues of the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.