MSP-5 nucleic acid molecules and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorMehran M. Khodadoust
Life of this patent
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Abstract
The invention provides isolated nucleic acid molecules, designated MSP-5 nucleic acid molecules, which encode novel myocardium secreted proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MSP-5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing MSP-5 polypeptides.
Claims92
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1, or a full complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:3, or a full complement thereof.
An isolated nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:1, or a full complement thereof.
An isolated nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:3, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:2, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:4, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:4, or a full complement thereof.
Deleted and American Type Culture Collection inserted.
Deleted and inserted Myocardium Secreted Protein-5 (MSP-5).
An isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide having an MSP-5 activity, comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule consisting of SEQ ID NO:1 or SEQ ID NO:3 at 6×SSC at 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C.
An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, or a full complement thereof.
An isolated nucleic acid molecule consisting of a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, or a full complement thereof.
An isolated nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4.
An isolated nucleic acid molecule encoding a polypeptide consisting of an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4.
Dependencies are inferred from the claim text.