Flea protease proteins, nucleic acid molecules, and uses thereof
AssigneeHeska Corporation
InventorsGary L. Stiegler, Patrick J. Gaines
Life of this patent
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Abstract
The present invention relates to flea serine protease proteins; to flea serine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
Claims14
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a nucleic acid molecule comprising a nucleic acid sequence that encodes an amino acid sequence selected from the group consisting of SEQ ID NO:8, SEQ ID NO:22, SEQ ID NO:27, SEQ ID NO:32, SEQ ID NO:37, SEQ ID NO:42 and SEQ ID NO:47;
- and,
- (b) a nucleic acid molecule that is fully complementary to any of said nucleic acid molecules of (a).
A method to produce a protein, said method comprising culturing an isolated cell capable of expressing said protein under conditions whereby said protein is produced, said protein being encoded by a nucleic acid molecule selected from the group consisting of a nucleic acid molecule comprising a nucleic acid sequence that encodes an amino acid sequence selected from the group consisting of SEQ ID NO:8, SEQ ID NO:22, SEQ ID NO:27, SEQ ID NO:32, SEQ ID NO:37, SEQ ID NO:42 and SEQ ID NO:47.
Dependencies are inferred from the claim text.