Loading patent…
AssigneeThe Trustees of Columbia University in the City of New York
InventorsPaul B. Fisher, Zao-Zhong Su
Estimating the term…
This invention provides a method for determining whether a compound is capable of suppressing ras functions comprising: (a) contacting an effective amount of the compound with Ha-ras transformed cloned rat embryo fibroblast cells under conditions permitting the compound to suppress ras functions in the cells; and (b) determining the expression or inhibition of certain indicator gene or genes, thereby determining whether the compound is capable of suppressing ras function. This invention further provides the determined compound and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. This invention also provides methods for generating transcriptional switched Ha-ras transformed cloned rat embryo fibroblast cells. This invention also provides the generated cells and different uses of the cells.
A method for determining whether a compound is capable of suppressing the ras transformation phenotype comprising:
A method for determining whether a compound is capable of suppressing the ras transformation phenotype comprising:
A method for determining whether a compound is capable of suppressing the ras transformation phenotype comprising:
A method for determining whether a compound is capable of suppresing the ras transformation phenotype comprising:
Dependencies are inferred from the claim text.