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US 6,204,000 B1Granted
Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1
AssigneesThe United States of America as represented by the Department of Health and Human Services, The Johns Hopkins University
InventorsJin-Tang Dong, J. Carl Barrett, Patricia W. Lamb, John T. Isaacs
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Abstract
The isolation and characterization of a metastasis tumor suppressor gene KAI1 is disclosed and diagnostic methods and gene therapy approaches utilizing reagents derived from the nucleotide and deduced amino acid sequences of the KAI1 gene are provided.
Claims7
A method for detecting the presence of malignant cancer in a subject, said method comprising:
- comparing the level of KAI1 mRNA or KAI1 protein of said subject to the level of wild-type KAI1 mRNA or protein to determine the presence of a reduction of exression of KAI1 mRNA-or protein, wherein said reduction of expression indicates the presence of malignant cancer.
A method for detecting the presence of malignant cancer in a subject, said method comprising:
- comparing the glycosylation of the KAI1 protein of said subject to the glycosylation of the wild-type KAI1 protein to determine the presence of a change in glycosylation, wherein loss of glycosylation indicates the presence of malignant cancer.
Dependencies are inferred from the claim text.