Detection of prostate and other cancers by assaying for cancer-specific antigens having linked oligosaccharides which are at least triantennary
AssigneeMillennium Pharmaceuticals, Inc.
InventorsPhillips W. Robbins, Sadhana Prakash
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Abstract
A process for assaying for cancer of the prostate, comprising assaying a sample derived from a human for prostate specific antigen having a linked oligosaccharide which is at least triantennary. The assay may employ a binding molecule which binds to oligosaccharides that are at least triantennary, but does not bind to oligosaccharides that are monoantennary or diantennary. Such binding molecule may be a lectin such as PHA-L or an antibody to an oligosaccharide that is at least triantennary.
Claims2
A kit for detecting prostate specific antigen linked to an oligosaccharide which is at least triantennary, comprising:
- (a) an antibody which recognizes an epitope of prostate specific antigen;
- (b) a solid support which supports said antibody;
- and
- (c) a binding molecule which binds to oligosaccharides which are at least triantennary but does not bind oligosaccharides which are biantennary or monoantennary.
Dependencies are inferred from the claim text.