Inhibition of smooth muscle cell migration by heme oxygenase I
AssigneeThe Regents of the University of Michigan
InventorsGary J. Nabel, Elizabeth G. Nabel
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Abstract
The present method provides a method for inhibiting restenosis associated with mechanical injury of a blood vessel. Human heme oxygenase I (HO1) is directly administered at the site of injury. The present inventors have discovered that carbon monoxide generated by HO1 is involved in the molecular pathogenesis of vascular proliferative disorders. By using adenoviral-mediated expression of inducible heme oxygenase 1 in primary vascular smooth muscle cells (vsmc) in vivo, the present inventors demonstrate that in vivo expression of HO1 can be used to treat restenosis.
Claims28
A method for inhibiting vascular smooth muscle cell proliferation, comprising contacting the cell in-vitro with an isolated nucleic acid encoding a heme oxygenase 1 gene, wherein expression of the heme oxygenase 1 gene inhibits proliferation of the cell.
A method of inhibiting vascular smooth muscle cell proliferation in-vivo, comprising locally administering to the patient an isolated nucleic acid encoding a heme oxygenase 1 gene, wherein expression of the heme oxygenase 1 gene inhibits proliferation of a vascular smooth muscle cell.
A medical device comprising an isolated nucleic acid encoding HO1.
Dependencies are inferred from the claim text.