Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection
AssigneeUniversity of Iowa Research Foundation
InventorsLarry S. Schlesinger, Bradley E. Britigan
Life of this patent
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Abstract
This invention relates to the use of gallium-containing compounds, to inhibit intracellular pathogens including pathogens that are members of the genus Mycobacteria, Legionella, Histoplasma, and Leishmania and to organisms causing chronic pulmonary infection such P. aeruginosa.
Claims18
A method for inhibiting growth of an intracellular pathogen comprising delivering a therapeutically effective dose of a gallium-containing compound in a pharmaceutically acceptable buffer to a mammal having cells infected with an intracellular pathogen as a result of phagocytosis.
The method of claim, wherein the cells are mononuclear phagocytes.
A method for inhibiting growth of an intracellular pathogen comprising delivering a therapeutically effective dose of a gallium-containing compound in a pharmaceutically acceptable buffer to a mammal having cells infected with an intracellular pathogen as a result of phagocytosis, wherein the pathogen is selected from the group consisting of Legionella, Histoplasma, and Leishmania.
A method for inhibiting growth of an intracellular pathogen comprising delivering a therapeutically effective dose of a gallium-containing compound in a pharmaceutically acceptable buffer to a mammal having cells infected with an intracellular pathogen as a result of phagocytosis, wherein the pathogen is Mycobacterium tuberculosis.
Dependencies are inferred from the claim text.