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AssigneeAlza Corporation
InventorsMichel J. N. Cormier, Peter E. Daddona, Juanita A. Johnson
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Transdermal compositions, devices, and methods for the administration of a drug at reduced skin irritation levels are disclosed. More particularly, this invention relates to novel methods, compositions, and devices for the reduction or elimination of irritation or sensitization caused by an irritating or sensitizing drug when it is delivered transdermally. According to a preferred embodiment, transdermal administration of a drug salt of a non-zwitterionic drug is disclosed wherein the drug salt comprises a combination of surface activity and a low octanol-water partition coefficient. Such drug salts have been found to reduce irritation or sensitization to the drug being delivered while achieving therapeutically effective transdermal fluxes.
A device for administering through the skin a therapeutically effective amount of an irritating, non-zwitterionic drug over an administration period, said device comprising:
A method for reducing skin or mucosal irritation during administration through the skin of a therapeutically effective amount of an irritating, non-zwitterionic drug over an administration period comprising:
A method for reducing the skin depot of drug accumulated in the skin during administration through the skin a therapeutically effective amount of an irritating non-zwitterionic drug over an administration period comprising the steps of:
Dependencies are inferred from the claim text.