Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
AssigneeSociete L'Oreal S.A.
InventorsOlivier De La Charriere, Lionel Breton
Life of this patent
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Abstract
The invention concerns the use of a substance P antagonist in a cosmetic composition used to treat sensitive skin. More specifically, the invention relates to a substance P antagonist used to prevent and/or combat skin irritations, desquamation, erythemas, sensations of dysesthesia/overheating, or pruritus of the skin.
Claims44
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:
- (1) an amount of at least one irritant substance sufficient to elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen that does not include the use of a substance P antagonist, wherein said irritant substance is an active agent in said topical cosmetic regimen;
- (2) an amount of at least one substance P antagonist sufficient to prevent or alleviate said irritation when said composition is utilized in a topical cosmetic regimen on a user having capsaicin-sensitive skin, wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:
- (i) it elicits a pharmacological response in at least one of the following tests:
- (a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation;
- and
- (b) it inhibits the contraction of smooth muscle induced by substance P;
- and
- (3) a cosmetically acceptable medium.
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:
- (1) an amount of at least one irritant substance sufficient to elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen that does not include the use of a substance P antagonist, wherein said irritant substance is an active agent in said topical cosmetic regimen;
- (2) an amount of at least one substance P antagonist sufficient to prevent or alleviate said irritation when said composition is utilized in a topical cosmetic regimen on a user having capsaicin-sensitive skin, wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:
- (i) it exhibits a selective affinity for the NK1 receptors on the tachykinins;
- and
- (ii) it elicits a pharmacological response in at least one of the following tests:
- (a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation;
- and
- (b) it inhibits the contraction of smooth muscle induced by substance P;
- and
- (3) a cosmetically acceptable medium;
- wherein said topically applicable cosmetic composition comprises a galenic formulation selected from the group consisting of a solution or dispersion of the lotion or serum type, microgranulate dispersion, vesicular ionic or non-ionic dispersion, alcoholic or hydroalcoholic aqueous solution, cream, gel, emulsion of the oil-in-water or water-in-oil type, foam, aerosol, solid, and paste.
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:
- (1) an amount of at least one irritant substance sufficient to elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen that does not include the use of a substance P antagonist, and wherein said irritant substance is an active agent in said topical cosmetic regimen;
- (2) an amount of at least one substance P antagonist sufficient to prevent or alleviate said irritation when said composition is utilized in a topical cosmetic regimen on a user having capsaicin-sensitive skin, wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:
- (i) it elicits a pharmacological response in at least one of the following tests:
- (a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation;
- and
- (b) it inhibits the contraction of smooth muscle induced by substance P;
- and
- (3) a cosmetically acceptable medium;
- wherein said topically applicable cosmetic composition suitable for use in a cosmetic regimen is selected from the group consisting of a hair care composition, skin care composition, cleansing composition, sunscreen composition, and a mouth care composition.
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:
- (1) an amount of at least one irritant substance sufficient to elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen that does not include the use of a substance P antagonist, and wherein said irritant substance is an active agent in said topical cosmetic regimen;
- (2) an amount of at least one substance P antagonist sufficient to prevent or alleviate said irritation when said composition is utilized in a topical cosmetic regimen on a user having capsaicin-sensitive skin, wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:
- (i) it exhibits a selective affinity for the NK1 receptors on the tachykinins;
- and
- (ii) it elicits a pharmacological response in at least one of the following tests:
- (a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation;
- and
- (b) it inhibits the contraction of smooth muscle induced by substance P;
- and
- (3) a cosmetically acceptable medium;
- wherein said topically applicable cosmetic composition suitable for use in a cosmetic regimen is selected from the group consisting of a hair care composition, skin care composition, cleansing composition, sunscreen composition, and a mouth care composition.
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:
- (1) an amount of at least one irritant substance sufficient to elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen that does not include the use of a substance P antagonist, wherein said irritant substance is an active agent in said topical cosmetic regimen;
- (2) an amount of at least one substance P antagonist sufficient to prevent or alleviate said irritation when said composition is utilized in a topical cosmetic regimen on a user having capsaicin sensitive skin, wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:
- (i) it elicits a pharmacological response in at least one of the following tests:
- (a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation;
- and
- (b) it inhibits the contraction of smooth muscle induced by substance P;
- and
- (3) a cosmetically acceptable medium;
- wherein said topically applicable cosmetic composition comprises a galenic formulation selected from the group consisting of a solution or dispersion of the lotion or serum type, microgranulate dispersion, vesicular ionic or non-ionic dispersion, alcoholic or hydroalcoholic aqueous solution, cream, gel, emulsion of the oil-in-water or water-in-oil type, foam, aerosol, solid, and paste.
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:
- (1) an irritant substance which can elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen, wherein said irritant substance is an active agent in said topical cosmetic regimen;
- (2) at least one substance P antagonist wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:
- (i) it elicits a pharmacological response in at least one of the following tests:
- (a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation;
- and
- (b) it inhibits the contraction of smooth muscle induced by substance P;
- and
- (3) a cosmetically acceptable medium.
Dependencies are inferred from the claim text.