Red blood cells loaded with S-nitrosothiol and uses therefor
AssigneeDuke University
InventorsJonathan S. Stamler, Joseph Bonaventura
Life of this patent
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Abstract
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells.
Claims11
A method for reducing blood pressure in a mammal comprising the steps of:
- a) isolating the mammal's red blood cells;
- b) treating the mammal's red blood cells with a solution comprising S-nitrosocysteine, S-nitrosohomocysteine or S-nitrosocysteinylglycine;
- and
- c) readministering to the mammal the red blood cells.
A method for reducing blood pressure in a first human comprising the steps of:
- a) isolating red blood cells of a second human;
- b) treating the red blood cells with a solution comprising S-nitrosocysteine, S-nitrosohomocysteine or S-nitrosocysteinylglycine, thereby obtaining treated red blood cells;
- and
- c) administering to the first human the treated red blood cells.
A method for reducing blood pressure in a mammal, comprising administering red blood cells treated with a solution comprising S-nitrosocysteine, S-nitrosohomocysteine or S-nitrosocysteinylglycine to the mammal.
A method for reducing blood pressure in a mammal, comprising administering to the mammal a blood substitute comprising red blood cells treated with a solution comprising S-nitrosocysteine, S-nitrosohomocysteine or S-nitrosocvsteinylglycine.
A method for reducing blood pressure in a human, comprising administering red blood cells treated with a solution comprising S-nitrosocysteine to the human.
A method for reducing blood pressure in a human, comprising administering red blood cells treated with a solution comprising S-nitrosohomocysteine to the human.
A method for reducing blood pressure in a human, comprising administering red blood cells treated with a solution comprising S-nitrosocysteinylglycine to the human.
Dependencies are inferred from the claim text.