Poly(diallylamine)-based bile acid sequestrants
AssigneeGelTex Pharmaceuticals, Inc.
InventorsStephen Randall Holmes-Farley, Pradeep K. Dhal, John S. Petersen
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Abstract
The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.
Claims37
A method for removing bile acids from a human patient comprising the step of administering to the patient a therapeutically effective amount of a crosslinked poly(diallylarnine) polymer wherein more than 10% of the amino nitrogen atoms bear a C3-C24-alkyl group.
A method for removing bile acids from a human patient comprising the step of administering to the patient a therapeutically effective amount of a polymer characterized by a diallylamine monomer wherein the amino nitrogen atom is substituted with an ammonioalkyl group.
Dependencies are inferred from the claim text.