Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization
AssigneeThe Regents of the University of California
InventorRobert C. Brasch
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Abstract
The properties of a tissue extracellular space, particularly the microvascular component of that space can be characterized by the use of x-ray diagnostic modalities in conjunction with particulate contrast agents. The present invention provides a method for characterizing a property of a tissue extravascular space utilizing radiopaque particulate contrast. Moreover, the present invention provides a novel class of particulate agents suitable for use in conjunction with the methods provided herein.
Claims22
A method for determining a property of a tissue extracellular space comprising an intravascular space and an extravascular space, said method comprising:
- (a) delivering to a tissue intravascular space a particulate radiopaque agent, wherein said agent is not substantially phagocytized by cells of the reticuloendothelial system during at least a selected time period;
- (b) allowing said agent to distribute between said intravascular space and said extravascular interstitial space for said selected time period, wherein at least a portion of said particulate radiopaque agent distributes into said extravascular interstitial space during said selected time period, thereby forming a distribution of said agent;
- (c) measuring said distribution of said agent by obtaining at least one x-ray absorption data set of a region encompassing said extravascular interstitial space;
- and
- (d) determining said property from said data set.
Dependencies are inferred from the claim text.