Method for grafting a substituted difluoromethyl group
AssigneeRhodia Chimie
InventorsGérard Forat, Jean-Manuel Mas, Laurent Saint-Jalmes
Life of this patent
Estimating the term…
Abstract
Provided is a process for grafting a substituted difluoromethyl group onto a compound bearing at least one electrophilic substituent, comprising (i) contacting the compound bearing at least one electrophilic substituent with a nucleophilic reagent which comprises (a) a fluorocarboxylic acid having the formula Ea—CF2—COOH, wherein Ea is an electron-withdrawing atom or group, the fluorocarboxylic acid being at least partially salified with an organic or inorganic cation and (b) a polar aprotic solvent, and (ii) exposing the resulting medium of reaction to the action of microwave energy.
Claims28
A process for grafting a substituted difluoromethyl group onto a compound bearing at least one electrophilic substituent, comprising (i) contacting said compound bearing at least one electrophilic substituent with a nucleophilic reagent which comprises (a) a fluorocarboxylic acid having the formula Ea—CF2—COOH, wherein Ea is an electron-withdrawing atom or group, said fluorocarboxylic acid being at least partially salified with an organic or inorganic cation and (b) a polar aprotic solvent, thereby forming a medium of reaction, and (ii) exposing the resulting medium of reaction to the action of microwave energy.
Dependencies are inferred from the claim text.