Method of making and using a flexible, multiple-compartment drug container

A method for forming a flexible container for administration of IV solutions, the method comprising the steps of:

• providing a flexible front sheet;
• providing a flexible rear sheet, the front and rear sheets permanently sealed together around a portion of a common peripheral edge so as to define a volume enclosure therebetween, wherein at least one gap is present in the permanent seal;
• providing at least one sacrificial port interposed between the front and rear sheets and in communication with the volume enclosure;
• and
• heating the front and rear sheets in a first localized area to fuse together the heated portions of the adjoining surfaces, thereby forming extension seals in a portion of the container extending between two sides of the common peripheral edge and spaced-away from the at least one sacrificial port, the extension seals and the permanent seal gap defining a channel from said sacrificial port to said volume enclosure.

A method for forming flexible container for combined storage and administration of IV solutions, the method comprising the steps of:

• providing a flexible, transparent front sheet;
• providing a flexible, vapor impermeable rear sheet;
• heating the front and rear sheets in a first localized area to fuse together the heated portions of the adjoining surfaces, thereby forming a permanent seal around a portion of a common peripheral edge of said front and rear sheets, the permanent seal having at least one gap therein providing a channel between said front and rear sheets;
• and
• providing at least one sacrificial port interposed between the front and rear sheets and in communication with the channel for aseptically filling the container.

A method for forming a flexible container for combined storage and administration of IV solutions, the method comprising the steps of:

• providing a flexible, front sheet;
• providing a flexible, vapor impermeable rear sheet, the front and rear sheet sealed together at a common peripheral edge;
• heating the front and rear sheets in a first localized area to fuse together the heated portions of the adjoining surfaces, thereby forming a permanent seal, the permanent seal being interrupted along its length to define a channel formed between the front and rear sheets;
• providing at least one sacrificial port interposed between the front and rear sheets and in communication with the channel for aseptically filling the container;
• aseptically filling the container through the at least one sacrificial port;
• and
• completing the seal along the container's common peripheral edge and removing the at least one sacrificial port from the container, whereby container formation is completed without being subject to a sterilization step after the first compartment filling step.