Z-styryl sulfone anticancer agents
AssigneeTemple University-of the Commonwealth of Higher Education
InventorsE. Premkumar Reddy, M. V. Ramana Reddy
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Abstract
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, and fluoro; and R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, and fluoro; provided that at least one of R1 or R2 is hydrogen. The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.
Claims17
A compound of the formula
- wherein
- R1 is selected from the group consisting of hydrogen, chloro and nitro;
- R3 is selected from the group consisting of hydrogen, chloro, fluoro and bromo;
- and
- R2 and R4 are independently selected from the group consisting of chloro, fluoro and bromo.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of the formula:
- wherein
- R1 is selected from the group consisting of hydrogen, chloro and nitro;
- R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, and fluoro;
- and
- R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, and fluoro;
- provided at least one of R1 or R2 is hydrogen.
Dependencies are inferred from the claim text.