Polypeptide with reduced respiratory allergenicity
AssigneeNovo Nordisk A/S
InventorsArne Agerlin Olsen, Lars Bo Hansen, Thomas Christian Beck
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AssigneeNovo Nordisk A/S
InventorsArne Agerlin Olsen, Lars Bo Hansen, Thomas Christian Beck
Estimating the term…
The invention relates to modified polypeptides with reduced respiratory allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (Mr) in the range of 1 kDa and 60 kDa. The modified polypeptide are produced using a process including the step of conjugating from 1 to 30 polymer molecules with the parent polypeptide. Further the invention relates to compositions comprising said polypeptides and further ingredients normally used in e.g. detergents, including dishwashing detergents and soap bars, household article, agrochemicals, personal care products, cosmetics, toiletries, oral and dermal pharmaceuticals, composition for treating textiles, and compositions used for manufacturing food and feed. Finally the invention is directed to uses of polypeptides with reduced allergenicity or compositions thereof for reducing the allergenicity of products for a vast number of industrial applications.
A composition comprising (a) a modified protease, wherein said protease is conjugated to a polymer with a molecular weight in the range of 1 kDa to 60 kDa, wherein said modified protease exhibits reduced respiratory allergenicity relative to an unmodified protease and (b) a substance for industrial application which renders the composition unsuitable for pharmaceutical use.
Dependencies are inferred from the claim text.