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US 6,200,559 B1Granted
Use of antibodies against MxA or MxB to determine levels of type I interferons in vivo
OwnerPeter von Wussowinventor
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Abstract
The invention provides methods of indirectly measuring the level of type I interferons in vivo utilizing antibodies directed against MxA and/or MxB. The methods find application in conjunction with therapies directed to raising or lowering the levels of interferons in patients. Also provided are new monoclonal antibodies that recognize specific human Mx protein(s).
Claims15
An antibody selected from the group consisting of:
- monoclonal antibody 2-95 (DSM 2289) or a fragment or conjugate thereof that specifically binds to MxA and MxB;
- monoclonal antibody 5-237 (DSM 2290) or a fragment or conjugate thereof that specifically binds to MxA and MxB;
- monoclonal antibody 8-271 (DSM 2308) or a fragment or conjugate thereof that specifically binds to MxB;
- and
- monoclonal antibody 7-88 (DSM 2309) or a fragment or conjugate thereof that specifically binds to MxB.
2 more elements
Dependencies are inferred from the claim text.