Transfection system, its preparation and use in somatic gene therapy
AssigneeCardiogene Gentherapeutische Systeme AG
InventorJurgen Schrader
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Abstract
The present invention relates to a transfection system comprising one or more Infiltrator catheters, one or more non-viral nucleic acids, and, where appropriate, suitable ancillary substances and/or additives, and to its preparation and use in somatic gene therapy.
Claims15
A method of delivering a composition comprising one or more non-viral nucleic acids to a vessel wall which comprises administering said nucleic acids by a catheter which comprises a central tubular shaft, an inflatable balloon, which envelopes the shaft at the distal end, and a tubular sleeve that envelops the balloon which comprises one or more injector parts.
A method for treating and preventing vascular disorders, genetically related disorders and/or disorders which can be treated by gene transfer in a host in need thereof, which comprises delivering one or more nonviral nucleic acids to a vessel wall in said host by a catheter which comprises a central tubular shaft, an inflatable balloon, which envelopes the shaft at the distal end, and a tubular sleeve that envelopes the balloon, which comprises one or more injector ports.
Dependencies are inferred from the claim text.