Method and apparatus for combining injury-mediated therapy and drug delivery
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMichael J. Mann, Umer Sayeed-Shah, Victor Dzau, Lawrence H. Cohn
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Abstract
A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e.g., muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal probe, and (ii) injecting into the tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecules Also described is an apparatus that can be used to practice this method.
Claims28
A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, said method comprising the steps of:
- i) creating a track to tissue injury in said tissue, and
- ii) injecting into said tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecule, wherein the track of the injection is in a predetermined direction relative to but not within, said tack of tissue injury,
- said method resulting in improvement of a condition of said disease to a greater degree than results from injury-induced revascularization treatment alone.
A method of increasing expression of a gene in a tissue, said method comprising the steps of;
- i) creating a track tissue injury in said tissue, and
- ii) injecting into said tissue a nucleic acid molecule comprising said gene, wherein the track of the injection is in a predetermined direction relative to buy within said track of tissue injury,
- said method resulting in increased expression of said gene compared to expression that results firm injection of said nucleic acid molecule alone.
Dependencies are inferred from the claim text.