Integrated nucleic acid diagnostic device
AssigneeAffymetrix, Inc.
InventorsRolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Abstract
The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
Claims8
A method of directing a fluid sample in a miniature fluidic system, comprising:
- providing a microfabricated device having at least first and second chambers disposed therein, wherein each of said at least first and second chambers is in fluid connection with a common chamber or channel, has at least first and second controllable valves disposed across said fluid connection, respectively, and wherein at least one of said first and second chambers include a vent;
- applying a positive pressure to said common chamber or channel;
- selectively opening said at least first controllable valve, whereby said positive pressure forces said fluid sample from said common chamber or channel into said first chamber.
Dependencies are inferred from the claim text.