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US 6,197,528 B1Granted
Composition of immunotoxins and retinoids and use thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsYouNeng Wu, Richard J. Youle
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Abstract
The present invention relates to compositions of retinoids plus immunotoxins. More particularly this invention relates to the use of retinoids to potentiate the activity of immunotoxins for treatment of mammalian diseases.
Claims8
An in vitro method to screen for a retinoid that is capable of potentiating the activity of an immunotoxin comprising:
- (a) exposing mammalian target cells to an immunotoxin and a retinoid to be screened for potentiating activity;
- (b) assessing growth inhibition of the target cells relative to control cells that are exposed to said immunotoxin alone;
- and
- (c) correlating the growth inhibition of the target cells relative to the control cells with the potentiating ability of said retinoid on said immunotoxin.
1 more element
Dependencies are inferred from the claim text.