Method of producing a sustained-release preparation
AssigneeTakeda Chemical Industries, Ltd.
InventorsYutaka Yamagata, Masafumi Misaki, Susumu Iwasa
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Abstract
A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic solvent, followed by removing the organic solvent; which provides a sustained-release preparation showing a high entrapment ratio of the physiologically active polypeptide and its constant high blood concentration levels over a long period of time.
Claims11
A method of producing a sustained-release preparation which comprises dispersing a physiologically active polypeptide into a solution of a lactic acid/glycolic acid copolymer, wherein a molecular composition ratio of lactic acid/glycolic acid in the acid/glycolic acid copolymer is about 85/15 to about 50/50 and zinc oxide in an organic solvent, followed by removing the organic solvent.
A dispersion which is prepared by dispersing a physiologically active polypeptide into a solution of lactic acid/glycolic acid copolymer and zinc oxide in an organic solvent.
Dependencies are inferred from the claim text.