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US 6,197,349 B1Granted
Particles with modified physicochemical properties, their preparation and uses
AssigneeKnoll, Inc.
InventorsKirsten Westesen, Britta Siekmann
Life of this patent
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Abstract
Particles comprising (a) a supercooled melt of a poorly water-soluble substance and (b) a stabilizing agent, which have a mean particle size of between 30 and 500 nm, and disperse compositions containing them, as administration forms and delivery systems for drugs, vaccines and other biologically active agents such as herbicides, pesticides, insecticides, fungicides, fertilizers, vitamins, nutrition additives and cosmetics.
Claims17
Particles having a mean particle size of between 30 and 500 nm comprising
- (a) a supercooled melt of a poorly water-soluble substance and
- (b) a stabilizing agent, which particles are the product of the process comprising melting said poorly water-soluble substance, and mixing and dispersing together said poorly water-soluble substance with said stabilizing agent,
- optionally in the presence of a dispersion medium, followed by cooling without crystallization.
The particles of 1, further comprising a bioactive agent.
Dependencies are inferred from the claim text.