Process for preparing biaryl compounds
AssigneeCatalytica, Inc.
InventorsJoseph A. Miller, Robert P. Farrell
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Abstract
The present invention provides a process for preparing biaryl compounds comprising reacting an arylzinc reagent with an arylchloride in the presence of a nickel catalyst or a palladium catalyst. The present invention specifically provides a process for the preparation of 2-(4′-methylphenyl)benzonitrile comprising reacting a 4-methylphenylzinc reagent with 2-chlorobenzonitrile in the presence of a nickel catalyst or a palladium catalyst.
Claims20
A process for the preparation of biaryl compounds of the formula Ar-Ar′, wherein Ar and Ar′ are aryl groups and may be identical or different, comprising reacting an arylzinc reagent comprising the aryl group Ar bonded to zinc with an arylchloride of the formula Ar′Cl, wherein Ar′ is selected from phenyl, pyridyl, furyl, thienyl and pyrrolyl groups and substituted derivatives thereof, in the presence of a catalyst selected from the group consisting of nickel catalysts and palladium catalysts.
A process for the preparation of 2-(4′-methylphenyl)benzonitrile comprising reacting a 4-methylphenyizinc reagent with 2-chlorobenzonitrile in the presence of a catalyst selected from the group consisting of nickel catalysts and palladium catalysts.
In a process for the preparation of biaryl compounds by reacting an arylmetal reagent with an arylhalide in the presence of a catalyst selected from the group consisting of nickel catalysts and palladium catalysts, the improvement wherein the arylmetal reagent is an arylzinc reagent and the arylhalide is an arylchloride wherein the aryl group of the arylchloride is selected from phenyl, pyridyl, furyl, thienyl and pyrrolyl groups and substituted derivatives thereof.
Dependencies are inferred from the claim text.