Tricyclic polyhydroxylic tyrosine kinase inhibitors

A compound of formula I

• wherein
• Q is
• at least three and no more than four of R2, R3, R4, R5, R6, R7, and R8 are OH, the remainder being H;
• R9 is H or halo;
• Z1 is H, benzyl, alkyl(C1-C4), —(CH2)n—phenyl—R22, —(CH2)n—dichlorophenyl,
• —SO2—R21, —CH2—pyridyl or
• wherein n is 0-3;
• R20 is H, t-butyl, CF3, —SO2—alkyl(C1-C4), halo, alkyl(C1-C4), phenyl or NO2;
• R21 is phenyl, alkyl(C1-C4), benzyl, nitrophenyl, dichlorophenyl or halophenyl;
• R22 is —C≡N, CF3, phenylsulfonyl, halo or alkyl(C1-C4);
• and
• the pharmaceutically-acceptable cationic salts and prodrugs thereof.