Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
AssigneeHoechst Aktiengesellschaft
InventorsPeter Hammann, Johannes Meiwes, Gerhard Seibert, László Vertesy, Joachim Wink, Astrid Markus
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Abstract
The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.
Claims12
Lipopeptides of the formula I
- in which R1 is a singly or multiply unsaturated branched or unbranched or a saturated branched or unbranched fatty acid with a chain length of 12, 13, 14, or 15 carbon atoms and R2 is Asn.
Actinoplanes sp. DSM 7358.
Dependencies are inferred from the claim text.