Device for delivery of multiple liquid sample streams to a mass spectrometer
AssigneeSynsorb Biotech, Inc.
InventorsOle Hindsgaul, David C. Schriemer
Life of this patent
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Abstract
An electrospray apparatus employing multiple electrospray needles mounted on a rotatable plate sequentially delivers multiple sample streams to a mass spectrometer for analysis. The electrospray device includes an electrospray chamber, a rotatable needle supporting plate, a plurality of electrospray needles mounted on the plate, and a charger for applying a charge to droplets delivered to the electrospray chamber by the needles. The rotatable electrospray apparatus provides fast repetitive screening of simultaneously operating chromatography columns with a single mass spectrometer.
Claims23
An electrospray device for a mass spectrometer comprising:
- a substantially circular arrangement of electrospray needle, the electrospray needles connectable to a plurality of sample streams for delivery of droplets of the sample streams to a mass spectrometer orifice;
- a rotatable member for directing droplets of one of the sample streams at a time to the mass spectrometer orifice;
- and
- a charger for applying a charge to the droplets of the sample stream and causing ions to be focused into a beam passing through the mass spectrometer orifice.
A method of delivering a plurality of sample streams to a mass spectrometer for sequential analysis, the method comprising:
- providing a plurality of sample streams to a plurality of electrospray needles mounted on a support plate;
- continuously spraying the sample streams with the electrospray needles;
- and
- sequentially providing an outlet of each of the electrospray needles at a delivery position for a predetermined dwell time to deliver the sample streams to the mass spectrometer.
A system for analyzing a plurality of fluid samples, the system comprising:
- a mass spectrometer;
- an electrospray needle array for continuously spraying the plurality of fluid samples towards the mass spectrometer;
- and
- a movable member for delivering one of the plurality of sample streams at a time to the mass spectrometer.
Dependencies are inferred from the claim text.