Transgenic mice expressing the HIK-ras 4B chimeric gene
AssigneeLG Chemical Ltd.
InventorTae Saeng Choi
Life of this patent
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Abstract
A transgenic mouse whose genome comprises the H/K-ras 4B chimeric gene to form a mammary tumor and, particularly, the expression vector producing H/K-Ras 4B chimeric protein by using MMTV (mouse mammary tumor virus) promoter. This protein contains the first 164 amino acids of the H-Ras followed by the last 24 amino acids of K-Ras 4B. The second, it relates to the transgenic mouse expressing the H/K-Ras 4B protein with a mammary tumor, and the third, the method of preparation.
Claims7
A transgenic mouse having a mammary tumor whose genome comprises a mammalian H/K-ras 4B gene operably linked to a mouse mammary tumor virus (MMTV) promoter, wherein the H/K-ras 4B transgene is expressed in somatic cells and germ cells, and wherein said expression results in said mammary tumor.
An expression vector comprising pMAMneo comprising a H/K-ras 4B gene under the control of the mouse mammary tumor virus (MMTV) promoter.
Dependencies are inferred from the claim text.