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US 6,191,288 B1Granted
Pyronin antibacterials, process and novel intermediates thereto
AssigneeAnadys Pharmaceuticals, Inc.
InventorP. Siva Ramamoorthy
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Abstract
The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
Claims13
A method of producing intermediates useful in the synthesis of pyronin antibacterials comprising the steps of:
- (a) alkylating a pyrone of the formula:
- with an alkyl halide of the formula
- wherein X is selected from the group consisting of Br, I, and Cl, and R is independently selected from the group consisting of alkyl and trialkylsilyl to form a first intermediate compound of the formula:
- and
- (b) deprotecting the first intermediate compound to form a second intermediate compound of the formula:
2 more elements
A process for the preparation of an acyl pyrone with the structure
- comprising contacting a pyrone of the formula:
- with a lithium base, and
- reacting said lithium base-treated compound with a compound of the formula
Dependencies are inferred from the claim text.