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US 6,191,287 B1Granted
Process for selective derivatization of taxanes
AssigneeFlorida State University
InventorsRobert A. Holton, Zhuming Zhang, Paul A. Clarke
Life of this patent
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Abstract
Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.
Claims9
A process for the silylation of a C(10) hydroxy group of a taxane, the process comprising treating the taxane with a silylamide or a bissilylamide to form a C(10) silylated taxane.
Dependencies are inferred from the claim text.