Substituted 5-membered ring heterocycles comprising a bicyclic or tricyclic group their preparation and their use

5-Membered ring heterocycle of the formula I,

• in which
• W represents R1-A—C (R13) or R1-A—C═C;
• Y represents a carbonyl group, a thiocarbonyl group or a methylene group;
• Z represents N (R0), oxygen, sulphur or a methylene group;
• A denotes a (C1-C6)-alkylene, (C3-C7)-cycloalkylene, phenylene, phenylene-(C1-C6)-alkyl, (C1-C6)-alkylene-phenyl or phenylene-(C2-C6)-alkenyl divalent radical, or a divalent radical of a 5-membered or 6-membered saturated or unsaturated ring containing 0, 1 or 2 nitrogen atoms and substituted by 0, 1, or 2 (C1-C6)-alkyl or doubly bonded oxygen or sulphur;
• B denotes a (C1-C6)-alkylene, (C2-C6)-alkenylene, phenylene, phenylene-(C1-C3)-alkyl or (C1-C3)-alkylene-phenyl divalent radical;
• D represents C(R2) (R3), N(R3) or CH═C(R3);
• E denotes tetrazolyl, (R8O)2P(O), HOS (O)2, R9NHS (O)2or R10CO;
• R and R0 denote, independently of each other, hydrogen, (C1-C8) alkyl, (C3-C8) alkyl, (C3-C8)-cycloalkyl, substituted or unsubstituted (C6-C14)-aryl, or (C6-C14)-aryl-(C1-C8)-alkyl which is substituted or unsubstituted in the aryl radical;
• R1 represents X—NH—C (═NH)—(CH2)p or X1-NH-(CH2)p, where p is an integer from 0 to 3;
• X denotes hydrogen, (C1-C6) alkyl, (C1-C6) alkylcarbonyl, (C1-C6) -alkoxycarbonyl, C1-C18)-alkylcarbonyloxy-(C1-C6)-alkoxycarbonyl, substituted or unsubstituted (C6-C14)-arylcarbonyl, substituted or unsubstituted (C6-C14)-aryloxycarbonyl, (C6-C14)-aryl-(C1-C6)-alkoxycarbonyl which is unsubstituted or substituted in the aryl radical (R8O)2P(O), cyano, hydroxyl, (C1-C6)-alkoxy, (C5-C14)-aryl-(C1-C6)-alkoxy which is substituted or unsubstituted in the aryl radical, or amino;
• X1 has one of the meanings of X or denotes R′-NH—C (═N—R″), where R′ and R″, independently of each other, have the meanings of X;
• R2 denotes hydrogen, (C1-C8)-alkyl, substituted or unsubstituted (C6-C14)-aryl, (C6-C14)-aryl-(C1-C8)-alkyl which is substituted or unsubstituted in the aryl radical, (C3-C8)-alkyl which is substituted or unsubstituted in the aryl radical, or (C3-C8)-cycloalkyl;
• R3 denotes COOR15, CON (CH3)R15 or CONHUR15;
• R8 denotes hydrogen, (C1-C18)-alkyl, substituted or unsubstituted (C6-C14)-aryl or (C6-C14)-aryl-(C1C8)-alkyl which is unsubstituted or substituted in the aryl radical;
• R9 denotes hydrogen, aminocarbonyl, (C1-C18)-alkylaminocarbonyl, (C3-C8)-cycloalkylaminocarbonyl, substituted or unsubstituted (C6-C14)-arylaminocarbonyl, (C1-C18)-alkyl, substituted or unsubstituted (C6-C14)-aryl, or (C3-C8)-cycloalkyl;
• R10 denotes hydroxyl, (C1-C18)-alkoxy, (C6-C14)-aryl-(C1-C8)-alkoxy which is unsubstituted or substituted in the aryl radical, substituted or unsubstituted (C6-C14)-aryloxy, amino or mono- or di-((C1-C18)-alkyl)-amino;
• R13 denotes hydrogen, (C1-C6)-alkyl, (C6-C14)-aryl-(C1-C8)-alkyl which is substituted or unsubstituted in the aryl radical, or (C3-C8)-cycloalkyl;
• R15 represents R16-(C1-C6)-alkyl or represents R16;
• R16 represents 6- to 24-membered bicyclic or tricyclic radical which is saturated or partially unsaturated and which contains form zero to four identical or different heteroatoms from the group nitrogen, oxygen and sulphur, and which is unsubstituted or substituted by one or more identical or different sustituents from the group (C1-C4)-alkyl and oxo;
• b, c, d, and f, independently of each other, represent 0 or 1, but cannot all simultaneously be 0;
• e, g, and h, independently of each other, represent integers from 0 to 6;
• where, however, when at the same time, W represents R1-A—CH or R1-A—CH═C, D represents N (R3) and c, d, and f represent 0, R3 cannot when represents COORa where Ra represents methyl which is substituted by a 9-fluorenyl radical, or the physiologically tolerated salts thereof.