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US 6,191,273 B1Granted
Substituted cyclic compounds and mixtures comprising same
AssigneeIsis Pharmaceuticals, Inc.
InventorsPhillip Dan Cook, Haoyun An, Becky Haly, Tingmin Wang
Life of this patent
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Abstract
Novel chemical compounds and mixtures of same are provided having antibacterial and other utilities. The mixtures preferably are formed by reacting a cyclic scaffold moiety with a set of chemical substituients. Libraries formed in accordance with the invention have utility per se and are articles of commerce. They can be used to screen for pesticides, drugs and other biologically active compounds.
Claims3
A compound having the formula:
- wherein:
- Z is NH, O, or S;
- n is 0 or 1;
- and
- L is a substituent selected from the group consisting of guanidinylarylalkyl, aminoarylalkyl, amidinylpiperazinylcarbonylalkyl, piperazinylcarbonylalkyl, amidinylpiperazinylcarbonylarylalkyl, piperazinylcarbonylarylalkyl, guanidinylalkylaminocarbonylalkyl, aminoalkylaminocarbonylalkyl, guanidinylalkylaminocarbonylarylalkyl, aminoalkylaminocarbonylarylalkyl, benzoimidazolylalkyl, amidinyl, hydroxyamidinyl, hydroxyalkylpyridinylalkyl, arylalkyl, cinnamyl, amidylalkyl, aroyl, alkyloyl, aminoalkyloyl, hydroxaminoyalkyloyl, methoxyaminothioalkyloyl, indolylaminoalkyloyl, amidylaminoalkyloyl, hydroxylcarbonylaminoalkyloyl, guanidinylaminoalkyloyl, imidazolylaminoalkyloyl, amino substituted acyl, carboxyl-substituted arylalkyl and carboxylalkyl-substituted arylalkyl, hydroxysulfonylalkyl, alkyloxycarbonyl substituted pyrimidinyl, alkyloxycarbonyl substituted pyridinyl, carboxyl substituted pyrmidinyl, carboxyl substituted pyridinyl, guanidinylcarbonylalkyl, guanidinylcarbonylarylalkyl, guanidinylcarbonyl substituted pyrimidinyl, guanidinylcarbonyl substituted pyridinyl, alkyloxyphosphatealkyl, pyridinylalkyl, cyanoalkyl, cyanoaryl, nitroalkyl, nitroaryl, alkyloxyalkyl, phenolylalkyl, hydroxylarylalkyl, hydroxyquinolinylalkyl, alkylaminocarbonyl, arylaminocarbonyl, furanylaminocarbonyl, thiofuranylaminocarbonyl, alkylaminothiocarbonyl;
- arylaminothiocarbonyl, furanylaminothiocarbonyl, thiofuranylaminothiocarbonyl, pyridinylaminothiocarbonyl, 1,2,3-oxadiazolylalkyl, anthraquinone-2-methyl, pyrene-1-butyryl, anthraquinone-2-carbonyl, pyrene-1-carbonyl, 5-(anthraquinone-2-carbonyl)amino-1-pentanyl, 5-(pyrene-1-carbonyl)amino-1-pentanyl, [[[2-(anthraquinone-2-carbonyl)amino]ethylamino]carbonyl]methyl, [[[2-pyrene-1-carbonyl)amino]ethylamino]carbonyl]methyl, and [5-pyrene-1-carbonyl)amino]pentanoxy;
- or L is a conjugate group.
4 more elements
Dependencies are inferred from the claim text.