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US 6,191,271 B1Granted
Synthetic divalent sLex containing polylactosamines and methods for use
AssigneeGlycim Oy
InventorsOssi Renkonen, Risto Renkonen
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Abstract
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs and their use to block lymphocyte binding to correspondent oligosaccharides on the endothelial surface, and thus reduce or otherwise ameliorate an undesired inflammatory response. The invention is further directed to the use of such constructs in other disease states characterized by selectin binding, such as bacterial infections and metastatic cancers.
Claims7
A synthetic oligosaccharide having the formula:
- wherein
- Gal is galactose;
- GlcNAc is N-acetylglucosamine;
- Y is Galβ1-4GlcNAc or Galβ1-4(Fucα1-3)GlcNAc, wherein Fuc is fucose sLex is NeuNAcα2-3Galβ1-4(Fucα1-3)GlcNAc, wherein NeuNAc is sialic acid;
- and
- A is≧1.
3 more elements
Dependencies are inferred from the claim text.